Side-effect can mean:
- Adverse drug reaction, an unintended consequence specifically arising from drug therapy
- Therapeutic effect, a desirable consequence of any kind of medical treatment, even though resulting as an unintended, unexpected consequence of the treatment
- Adverse effect (medicine), an unintended, and undesirable, consequence of any kind of medical treatment
- Unintended consequence, an effect that is unforseen, regardless of type or quality
- Side-effect (computer science), a state change caused by a function call
- Side Effects, a collection of short stories by Woody Allen
- The Side Effects, a 1980s indie rock band
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