The word substrate can mean the following:
- Wafer (electronics), in the semiconductor industry, a wafer of material, normally a single crystal, upon which semiconductor devices can be fabricated
- Neural substrate, in neuroscience, the set of brain structures that underlies a specific behavior or psychological state
- Substratum, in linguistics, refers to linguistic influences that are transmitted from the language originally spoken in a given region into a new language; see also language shift
- Substrate, in plating, a metal which is plated with another metal which has different physical properties
- Substrate, in construction, a surface to which a substance is adhered
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